Prevalence of Psychiatric Comorbidity Among Patients With Substance Use DisorderPresenting to Psychiatry Department of A Tertiary Care Centre in South India - A CrossSectional Study

Abstract

 Background: Substance use disorders (SUDs) are associated with significant psychiatric comorbidities, complicating diagnosis and treatment outcomes. However, data on psychiatric comorbidities in SUD patients from South India remain limited. This study investigates the prevalence of psychiatric comorbidities among patients with SUDs in a tertiary care setting in South India. Methods: A cross-sectional study was conducted at Travancore Medical College, Kollam. Patients clinically diagnosed with SUDs as per ICD- 11 criteria were included after one month of abstinence. Psychiatric comorbidities were assessed using the Mini-International Neuropsychiatric Interview (MINI). Sociodemographic data, substance use patterns, and physical comorbidities were ana-lyzed. Results: Of 130 participants, 20.8% were diagnosed with psychiatric comorbidities. Mood disorders were the most common (10%), including major depressive disorder (4.6%). Anxiety disorders and psychotic disorders were observed in 3.1% and 1.5%, respectively. Alcohol dependence was most frequent, with 20.2% of these patients having comorbidities. Nicotine dependence showed the highest comorbidity rate (27.1%). Unemployment and longer substance use duration were significantly associated with comorbidi ties. Conclusion: This study highlights the prevalence of psychiatric comorbidities in SUD patients in South India, emphasizing the need for integrated care models. Findings provide a foundation for tailored interventions and inform public health strategies to address dual diagnoses effectively.