Association between Monocyte to High-Density Lipoprotein Ratio and Diabetic Nephropathy

Abstract

 Diabetes mellitus (DM) is a chronic disease affecting carbohydrate metabolism, contributing significantly to global morbidity and mortality. Among its complications, diabetic nephropathy (DN) stands out as the most prevalent, traditionally diagnosed through serum creatinine levels, urine protein creatinine ratio (UPCR), and estimated glomerular filtration rate (eGFR). However, the complexity and cost associated with these methods have spurred the search for a more accessible parameter. This study delves into the assessment of the Monocyte-High Density Lipoprotein ratio (MHR) as a potential predictor for DN development. One hundred participants were meticulously chosen and sorted into four groups based on plasma glucose, HbA1c, serum creatinine, UPCR, and eGFR. The calculation of MHR for each group revealed a statistically significant difference between controls and cases. Furthermore, a noteworthy negative correlation between eGFR and MHR was observed across the study groups. The findings suggest that MHR could serve as a straightforward and cost-effective tool in predicting both the onset and progression of Diabetic Nephropathy.