Guhan R. J Interesting Case of Valproate Induced Pancreatitis

Abstract

 Valproate is a commonly prescribed rst-line antiepileptic for both primary and secondary generalized seizures. However, it is crucial to be mindful of signicant complications, such as acute pancreatitis, linked to sodium valproate, especially when considering its use in populations like children and individuals with intellectual disabilities, who have unique susceptibilities in epilepsy and bipolar disorder treatment. In this case presentation, we discuss an instance of valproate-induced acute pancreatitis in a 22-year-old patient with a known history of mania over the past 6 months. The patient was initially prescribed oral sodium valproate at a dosage of 1g/day. Subsequently, oral valproate was promptly discontinued, and an alternative medication was initiated. Following one week of the new medication, the patient showed improvement, leading to discharge after 10 days with a prescription for Tab. Olanzapine 10 mg HS and Tab. Pacitane 2 mg OD. Notably, there was no recurrence of pancreatitis during subsequent follow-up.